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Synthesis of Some New Pyridazin-3-one Derivatives and Their Utility in Heterocyclic Synthesis
Faculty
Science
Year:
2010
Type of Publication:
Article
Pages:
534-537
Authors:
El-Mobayed, Medhat M, Hussein, Ahmed M, Mohlhel, Wafia M
DOI:
10.1002/jhet.357
Journal:
JOURNAL OF HETEROCYCLIC CHEMISTRY WILEY-BLACKWELL
Volume:
47
Research Area:
Chemistry
ISSN
ISI:000278638500008
Keywords :
Synthesis , Some , Pyridazin-3-one Derivatives , Their Utility
Abstract:
Synthesis of new heterocyclic compounds containing the pyridazinone moiety, which have a valuable biological activities, has been achieved through the nucleophilic addition of benzylamine to 4-(p-substituted phenyl)-4-oxo-2-butenoic acid 1a,b, followed by cyclocondensation of the adducts 2a,b to the corresponding pyridazin-3-one derivatives 3a,b. The behavior of the latter compounds toward different nucleophilic and electrophilic reagents was investigated. The structures of the newly synthesized compounds were elucidated by elemental analysis and spectroscopic data.
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