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Biochemical effect of a ketogenic diet on the brains of obese adult rats
Faculty
Pharmacy
Year:
2010
Type of Publication:
Article
Pages:
899-904
Authors:
Mohamed, Hoda E, El-Swefy, Sahar E, Rashed, Leila A, Abd El-Latif, Sally K
DOI:
10.1016/j.jocn.2009.11.005
Journal:
JOURNAL OF CLINICAL NEUROSCIENCE ELSEVIER SCI LTD
Volume:
17
Research Area:
Neurosciences \& Neurology
ISSN
ISI:000278788000018
Keywords :
Alzheimer disease, Amyloid protein precursor, Apolipoprotein E, Ketogenic diet, Neurodegeneration, Obesity
Abstract:
Excess weight, particularly abdominal obesity, can cause or exacerbate cardiovascular and metabolic disease Obesity is also a proven risk factor for Alzheimer's disease (AD) Various studies have demonstrated the beneficial effects of a ketogenic diet (KD) in weight reduction and in modifying the disease activity of neurodegenerative disorders. including AD Therefore, in this study we examined the metabolic and neurodegenerative changes associated with obesity and the possible neuroprotective effects of a KD in obese adult rats Compared with obese rats fed a control diet. obese rats fed a KD showed significant weight loss, improvement in lipid profiles and insulin resistance, and upregulation of adiponectin mRNA expression in adipose tissue In addition, the KD triggered significant downregulation of brain amyloid protein precursor, apolipoprotein E and caspase-3 mRNA expression, and improvement of brain oxidative stress responses. These findings suggest that a KD has anti-obesity and neuroprotective effects (C) 2009 Elsevier Ltd All rights reserved
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