Dietary Iron overload as Manipulated by Acid Unsaturation Types on some Organs of Experimental Rats

Iron fortified foods is considered by selected group of nutritionists asa cost-effective and long-term strategy to combat iron deficiency anemia.Such program was adopted and applied during last decades in differentcountries for certain varieties of bakeries especially breads. This concept was also recommended and supported by certain health authorities. However, their opponents on the other side presented different views andproofs warning seriously against iron toxicity and its consequences. Tenyears ago, Egyptian Ministry of Education, through its distributedinstitutes had adopted iron fortification program for different sectors ofstudents especially of young ages. It presented this in the form of ironfortified biscuits supplemented daily to students. Till now, this programwas not evaluated properly for such dietary modification. Chronic iron overload in subsequent to iron deposition in tissuesand organs can affect different pathological conditions like hereditaryhemochromatosis; a common inherited metabolic disorder due toincreased intestinal iron absorption, deposition in parenchymal cellsparticularly the liver, additionally defective erythropoiesis, chronic liverdisease and repeated red blood cells transfusion. The last case can bedemonstrated in thalassemia, sickle cell anemia and glucose-6-phosphatedehydrogenase (G-6-p DH) deficiency.