| Abstract: |
Stress is associated with the development of numerous diseases, such as gastric ulcer, cardiovascular diseases, cancer, immune system diseases , renal disorders ,respiratory diseases and psychological disorders. The present study was carried out to investigate the pathophysiological changes in male albino rats through the exposure of rats to sound stress for 10 minutes per hour for 3 month. The following parameters were determined; serum glucose level, serum lipid profile, insulin, corticosterone glutathione, glutathione peroxidase, superoxide dismutase , and glucose utilization . The present study was carried out in a trial to provide an approach about the effect of sound stress on diabetes mellitus.The obtained results can be summarized as follows:-I- Effect of sound stress on normal male rats.a- Stress produced non significant changes in serum glucose, insulin, the area under glucose ,HDL, GSH and GSH px levels .b- Stress significantly decreased cholesterol , LDL and corticosterone serum levels.c- Stress significantly elevated serum triglyceride and superoxide dismutase level.II –Effect of sound stress on STZ induced diabetes mellitus in rats:-A – Effect of STZ in different dose levels (25, 30 and 38 mg/kg) of stressed rats:1- Stressed rats injected with STZ in a dose 38mg/kgshowed a significant decrease in serum glucose level and the area under the glucose curve.2- Stressed rats injected with STZ in doses 25, 30 and 38mg/kg each in a separate group showed a significant decrease in serum cholesterol and LDL levels.3- Stressed rats injected with STZ in doses 25 and 30 mg/kg showed a significant increase in serum triglyceride and HDL levels.4- Stressed rats injected with STZ in doses 25 and 30 mg/kg showed a significant increase in GSH px levels.5- Stressed rats injected with STZ in doses 25, 30 and 38 mg/kg showed a significant increase in SOD levels.6- Stressed rats injected with STZ in doses 30 and 38 mg/kg showed a significant decrease in serum corticosterone levels.B- Effect of sound stress on young and adult diabetic rats (STZ in a dose 38mg/kg):1- Stressed diabetic young and adult rats showed a significant decrease in serum glucose levels and the total area under the glucose curve.2- Stressed diabetic young and adult rats showed a significant decrease in serum cholesterol, triglyceride, HDL and LDL levels.3- Stressed diabetic young and adult rats showed a significant increase in GSH px and SOD levels.4- Stressed diabetic young and adult rats showed a significant decrease in serum corticosterone levels.C- Effect of sound stress on the anti-diabetic activity of glimepiride in young and adult rats :1- Stressed diabetic treated young and adult rats showed a significant decrease in serum glucose level and the area under the glucose curve.2- Stressed diabetic treated young rats showed a significant decrease in serum cholesterol and LDL levels.3- Stressed diabetic treated young and adult rats showed a significant decrease in serum triglyceride levels.4- Stressed diabetic treated adult rats showed a significant decrease in serum HDL levels.5- Stressed diabetic treated young rats showed a significant increase in GSH levels.6- Stressed diabetic treated young and adult rats showed a significant increase in GSH px and SOD levels.7- Stressed diabetic treated young and adult rats showed a significant increase in serum insulin levels.8- Stressed diabetic treated young and adult rats showed a significant decrease in serum corticosterone levels.• In light of the given results of the present study, it could be concluded that:1- Stress may be participated in the production of different biochemical changes such as, increased serum triglyceride level, decreased serum glucose, corticosterone, cholesterol, HDLand LDL level , increased glutathione peroxidase and superoxide dismutase level these changes may participate a lot of pathophysiological effects in body systems.2- Subacute exposure to sound stress may produce abnormal biochemical & physiological effects . That successfully reduced the diabetogenic effect of STZ in rats .3- Stress potentiated the antidiabetic effect of glimepiride to the extent of hypoglycemia .This interaction could not be a general rule with all oral anti diabetic agents , because we studied this effect on one drug only . So further investigations should be carried out as a comparative study for the effect of sound stress on a lot of oral antidiabetic members of different classes.Concisely, stress as a daily life event may be involved in the development of different dysfuctions and diseases. Sound stress may exert an antagonistic effect to diabetes mellitus. Sound stress may in part potentiate the effect of some antidiabetic drugs that leads to a risk factors. Sound stress may play an important role in the complication of diabetes mellitus. Despite of these results, it is unfair to say that sound stress , as an effective type of pollution , is innocent of disturbing of carbohydrate metabolism . It will remain a potent factor for induction of many abnormalities in carbohydrate metabolism in humans. The species difference between rats and humanbeing is strongly affecting this assumption. Psychological effects and the difference in responses and interactions to the external stumuli between humanbeing and experimental animals should be taken into considerations .
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