| Abstract: |
The rule of axillary microflora in sweat odor formation is caused by the microbial biotransformation of odorless natural secretions into volatile odorous molecules. There are many classes of deodorants; the most important are the ones containing antibacterials and enzyme inhibitors. <A total of 100 specimens, were collected from axillae of healthy male and female human volunteers. These specimens yielded 190 isolates, 111(58.4℅) were Staphylococcus spp. and 45 (23.6℅) were Corynebacterium spp., while 34 (17.8℅) were Micrococcus spp. All isolates were found to be susceptible to common deodorant ingredients. Formaldehyde, ethylene glycol, propylene glycol, poly ethylene glycol 1540, glutraldehyde, musk xylol and triclosan; some natural plant products; mastics, bergamot oil, peppermint oil, vanillin, ascorbic acid, α-tocopherol acetate, selenium dioxide; some common enzyme inhibitors as orlistat, zinc sulphate, copper sulphate, EDTA, alum and triethyl citrateAll isolates were investigated for their ability to produce malodorous metabolites from testosterone oenanthate ester. Malodor producing isolates were detected by sensory assessment, and chromatographic assessment (TLC). Isolates were tested for their ability to produce malodor from another steroidal hormone, hydroxy progesterone caproate. Only lipophilic Corynebacterium isolates and Staphylococcus capitis strains were able to produce malodorous metabolites from testosterone ester. Only isolates that were found to be able to metabolize testosterone ester were able to metabolize hydroxy progesterone caproate, but no malodor was formed as a result to this metabolic reaction.
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