Evaluation of Solid Dispersions and Inclusion Complexes of Certain Poorly Water Soluble Anti - Fungal Drugs

Many antifungal drugs have poor water solubility, so it is important to increase the solubility of these drugs to improve their therapeutic effect.The aim of the work in the present thesis is to enhance the rate and extent of dissolution of two examples of poorly water soluble anti-fungal drugs namely ketoconazole and clotrimazole. Two techniques were employed: solid dispersion using polyvinyl pyrrolidone ( PVP ), polyethylene glycol (PEG), urea and sorbitol; inclusion complexation using β-cyclodextrin (β-CD).Many antifungal drugs have poor water solubility, so it is important to increase the solubility of these drugs to improve their therapeutic effect.The aim of the work in the present thesis is to enhance the rate and extent of dissolution of two examples of poorly water soluble anti-fungal drugs namely ketoconazole and clotrimazole. Two techniques were employed: solid dispersion using polyvinyl pyrrolidone ( PVP ), polyethylene glycol (PEG), urea and sorbitol; inclusion complexation using β-cyclodextrin (β-CD).