Pharmacological study on the effects of ACE inhibitors and angiotensin receptor blockers on the aluminium induced renal disorders in rats

In light of the results of the present study it could be concluded that• Al administration produces severe nephrotoxicity in rats, where oxidative stress plays an important role as evidenced by decreased kidney content of SOD and depletion of GSH in blood, catalase in plasma and increased LPO.• The present study demonstrates that benazepril and valsartan could be promising drugs for clinical use as nephroprotectors against aluminium-induced nephrotoxicity. Furthermore, this study sheds light on the mechanisms involved in their nephroprotective effect. They ameliorated the kidney injury induced by Al and guard against oxidative stress by restoring cellular defense mechanism, through increasing the kidney SOD content, increasing level of GSH and catalase and reducing LPO.• Benazepril and valsartan are equipotent in their nephroprotective and kidney treatment potential. Since the two drugs are used clinically this may simplify their introduction as protective and treatment agents.• Further investigations are clearly warranted to establish the clinical applicability of these drugs in patients with kidney diseases especially those associated with chronic renal failure.• We have to reduce our exposure to Al and pay attention to sources of Al in our foods, water and personal care products. It would be advisable that products destined for chronic renal patients have their composition re-evaluated in order to contain only components with reduced Al contamination.