Comparative study of the release of certain anti Inflammatory

NSAIDs have a world wide application for their effectiveness in treatment of many diseases as in alleviation of pain especially in rheumatoid arthritis and as analgesics in case of renal and biliary colics as well as for pain associated with menstruation and surgical operations. However, these drugs have several side effects especially on the digestive systems. These side effects could be bleeding or bleeding ulcers in stomach, duodenum or in the small intestine. For these reasons, many researches started to find out new formulations for these drugs for controlling their release to the body, thereby increasing patient compliance and minimizing the associated side effects.In the light of the above mentioned criteria the study in this thesis is concerned mainly with the possibility of formulation of sustained release tablets for certain NSAIDs by using different release retarding materials. For this study two NSAIDs, indomethacin and diclofenac sodium, were chosen and each drug was formulated into different tablet formulations using either direct compression technique (DCT) or wet granulation technique (WGT). The flowability of powders for direct compression or granules for wet granulation was studied by determination of such parameters as angle of repose and Carr’s index. For tablets evaluation, each of weight variation, hardness, friability and hardness to friability ratio as well as drug release rate from the prepared tablets at different pH according to USP monograph. In addition, this study included analysis of the data which are related to the release kinetics where the correlation coefficient (r) was calculated from which the order of the release kinetic was determined. On the other hand, the long term stability of the prepared tablets with respect to the physical properties and release characteristics, after storage at 25ºC, were assessed. Moreover, to ascertain the extent of the success of this study in contribution to preparation of sustained release NSAIDs containing tablets, comparison of certain tablet formulations to commercially available sustained release tablets, with respect to hardness and release