Physicochemial Study & Spectrofluorometric Determination of Certain Local Anesthetics

Four proceure were developed for the dtermintioan of some local anesthetic drugs, namely, benzocaine, benoxinate hydrochloride, butacaine sulphate, procaine hydrochloride and propoxycaine hydrochloride spectrofluorimetrically in pure form and in their pharmaceutical dosage forms. Iont addition, a stude of the effect of certain additives such as silicates, cyclodextrins and surfectants on the spectral profiles of the studied drugs was also carried out. Correlation between the RFI of the measured fluorophores and certain bulkiness parameters were also investigated.The thesis comprises two parts in addition to general introduction about the local anesthetic drugs especially the selected drugs and the differentioffical and reported method s described for the assay of these drugs.Part 1:In this par, the interaction between benoxinate hydrochloride, butacaine sulphate and propoxycaine hydrochloride with sodium montmorillonite (veegum) as an example of silicates, β-cyclodextrin (β-CD) as an example of cyclodextrins, cetylpyridinium chloride (CPC) as an example of cationic surfactants and sodium dodecyl sulphate (SDS) as an example of anionic surfactants were investigated.The absorpation spectra of benoxinage hydrochloride, butacaine sulphate and propoxycaine hydrochloride in aqueous solutions containging veegum at different pH level showed that the veegum suspensions slightly affect the absorption prociles but significantly