| Abstract: |
Resistance to antimicrobial agents due to misuse or overuse of these agents is a complex global issue. In this study the aim is to identify the klebsiella spp.-as nosocomial highly resistant organism -according to biotyping, serotyping, its sensitivity and resistance to some antibiotics, bacteriocin production and plasmid analysis, as well as relation with spreading as nosocomial infection. Its is evident that 11 (48%)of 23 strains containing plasmids have large plasmids 180,140,97 kbp either single as shown only in (13.3%)of respiratory isolates , or in combination with small plasmids as detected in 6 (40%) and 3 (50%) of respiratory isolates and urinary isolates respectively. Bacteriocin type {1,8} was the most predominant type represented 9 (39.1%) of 23 isolates containing plasmids. Seven of them (30.4%) were respiratory isolates. Among 9 (39.1%) klebocin strains type, {1,8},there were 3 strains harboring large plasmids97 , 140 , 180 kbp represented the same antibiotic resistance pattern against ampicillin, piperacillin, chloramphenoicol, trimethoprim, doxycycline, gentamicin, cephoperazone and ciprofloxacin antibiotics, some of them showed variability of resistant level.
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