Inhibition Of Hemolysin Transporter Protein By Multidrug Efflux Inhibitors In Escherichia Coli

The current study was undertaken to investigate the role of haemolysin transport system in efflux of antimicrobials and biocides andthe possible use of efflux inhibitors in combination with such agents.Escherichia coli is the most common causative agent of urinarytract infection. Escherichia coli was isolated from patients with clinicallydiagnosed urinary tract infection in a rate of 74.2%, and 22.5% of theisolates were found to be haemolytic. Twelve isolates produced hightitres of haemolysin, among which isolate No. 14 was the mosthaemolytic.The susceptibility profile of the haemolytic isolates to someantimicrobial agents used in UTI therapy and representatives of differentdrug groups was performed. The isolates showed complete resistance toerythromycin, azithromycin and chloramphenicol. Susceptibility rates of90%, 65% and 55% were found for gentamicin, polymyxin andstreptomycin, respectively. Susceptibility rates of 40% was found to thetested fluoroquinolones (ciprofloxacin, norfloxacin and ofloxacin) andof 20% for each of tetracycline, cefotaxime and cefoperazone.