Possible Theraputic Effects of CU(I)-Nicotinic Acid Complex on Adjuvant- Arthritic rats

Rheumatoid arthritis is a chronic destructive disease of joints, characterized by inflammation, synovial hyperplasia, and abnormal cellular and amoral immune responses. It is currently described to occur worldwide is about 1 % of the adult population.Many involved aspects of inflammation have not yet been examined in RA because of the limitations of obtaining multiple sequential tissue biopsies in humans. Hence, adjuvant induced arthritis is an animal immunological model of progressive joint swelling, destruction and bone erosion, has been shown to share certain clinical and immunological features with human RA. It is widely used, with a relatively high degree of validity, for testing anti-inflammatory and anti-rheumatic properties of drugs.The therapeutic approach of RA aims to suppress the inflammatory process in order to reduce pain and disability, and to prevent further joint destruction. Complete remission of RA means the disappearance of the disease activity either spontaneously or with anti-rheumatic therapy, without subsequent relapse. If it occurs infrequently, remission is the ultimate goal of therapy. Several lines of treatment are used for RA such as non-steroidal anti-inflammatory drugs and corticosteroids. Most of these drugs have many side effects. Nowadays the selective cyclooxygenase-2 inhibitors production ceasedand collected from pharmacies due to their threatening side effects on liver and heart. Because of these shortcomings, a more effective and safe therapeutic strategy is required to treat RA. In this field, many drugs possess modified pharmacological and toxicological properties when administered in the form of metallic complexes.