Biochemical & Toxicological Study on the Effect of Angiotensin II Receptor Antagonist Type I Versus Platelet-Derived Growth factor Inhibitor on the induced Renal Dysfunction in Experimental Animals

The aim of the present work implies the effectiveness of angiogenesis II type I receptor antagonist (Irbesartan), platelet derived growth factor inhibitor (Trapidi) and exogenous supplementation of nitric oxide precursor or its inhibitor (L-arginine, L-NAME) either alone or in combined form in reducing the progression of renal dysfunction induced by gentamicin in uninphrectornized and hypercholesterolemic uninephrectomized rats.The studied biochemical parameters were:1- In serum: creatinine, IL-lB, TNF -a, MCP -1, NO and minerals (Na, K, Ca ++, Mg ++)2- In plasma: cGMP and triacylglycerols.3- In renal tissue: oxidative stress markers (superoxideanion, lipid peroxides , SOD, CAT and GSH). In addition, histological examination for representative samples of renal tissue was carried out to demonstrate any cellular changes as correlated. the biochemical parameters.