Effect of Niridazole on the Biliary & Urinary Excretion of Some Heavy Metals

Administration of niridazole to normal rabbits revealed iron excertion in bile of animals . This iron exertion was found to be a result of metal drug chelating power . Six moles of niridazole were chelated with one iron atom in presence of glucuronic acid . A complex of mol . et . 1848 containing 3.03% iron was excerted in bile . No other cations were detectedAdministration of copper in an oral dose to normal rabbits followed by niridazole showed the excretion of one copper drug chelate of mo . et . 253 containing 49.8% copper in bile .However administration of zinc in an oral dose to normal rabbit followed by niriazole showed the appearance of two drug – zinc complex in bile , containing 16.1% and 50.6% zinc respectively . However iron was excerted in bile in double concentration compared with control animals . This finding could be explained by a possible activitation of zinc containing enzymes as positive modifiers for iron chelating