Studies on Factors Affecting the Microbial of Contamination of Certain Non Sterile Pharmaceuticals of Misr Company

The microbial content of 33o containers representing 110 batch of 22 pharmaceutical preparation produced by Misr Company for pharmaceutical Industries were examined. These Include 8 liquid oral preparations, 6 tablets, and 8 topical preparations. The microbloloylcal examination included the determination of total aerobic bacterial counts fungal count, as well as tests for S. auretis, Ps .aeruginosa, Salmonella ( in liquid oral preparation, and tablets) and Coliforms.It was found that 40 batches (100 %) of liquid oral pre¬paration showed bacterial counts of 0-l0/ml. for the fungal count 10 batches (25 %) showed counts of zero While 30 batches (75%) showed counts of 0-10/ml. All thebatches examined were -free from S.aureus, Ps .aeruglnosa, and Salmonella .Eight preparations con¬tained coli forms.3- As regard tablets, it was found that the number of batches showed bacterial counts of 10-102 was 7 (23,3 %), the number of showed ; bacterial counts of 10 - H/ was 23 (.76.7 %), the number of batches showing fungal count of < 10 was. 14 (46.6 %), the number of batches showing fungal counts pf 10 - 10 was11 (36.6 %} the number of batches showing fungal counts of 10 - 10 was .5 ( 15.6) . All the batches examined were free from S . aureus , Ps. Aeruginosa , Salmonella and califorms.