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Small-dense LDL and LDL glycation in metabolic syndrome and in statin-treated and non-statin-treated type 2 diabetes
Faculty
Pharmacy
Year:
2010
Type of Publication:
Article
Pages:
289-295
Authors:
Elseweidy, Mohamed M, Younis, Nahla N, Soran, Handrean, Charlton-Menys, Valentine, Durrington, Paul N, Sharma, Reena, Greenstein, Adam
DOI:
10.1177/1479164110383063
Journal:
DIABETES \& VASCULAR DISEASE RESEARCH SAGE PUBLICATIONS LTD
Volume:
7
Research Area:
Endocrinology \& Metabolism; Cardiovascular System \& Cardiology
ISSN
ISI:000285080700005
Keywords :
Glycaemic control, glycation, metabolic syndrome, small-dense LDL, statin, type 2 diabetes
Abstract:
Small-dense LDL (SD-LDL) has been particularly implicated in atherosclerosis It has previously been reported that in non-diabetic people SD-LDL is preferentially glycated The distribution of glycated apolipoprotein B (glyc-apoB) in lipoproteins in metabolic syndrome (MS) and in type 2 diabetes has not previously been studied Plasma apoB and glyc-apoB were determined in different apoB-containing lipoproteins including buoyant and SD-LDL in MS (n=18) and type 2 diabetes (DM) {[}n=48, 12 statin-untreated (DM S) and 36 statin-treated (DM+S)] Plasma glyc-apoB was 5 6 0 9, 3 5 0 5 and 4 0 0 2 mg/dl in DM S, DM+S and MS, respectively The glycated proportion of SD-LDL-apoB was greater than buoyant LDL in all groups SD-LDL contributed most to plasma glyc-apoB in DM S, because SD-LDL-apoB was higher in DM S than in MS and DM+S (p < 0 001) Plasma glyc-apoB correlated with SD-LDL-apoB (r=0 74, p < 0 0001 in diabetes and r=0 53, p < 0 001 in MS), but not with HbA(1c) SD-LDL is preferentially glycated in type 2 diabetes and MS Its concentration is a stronger determinant of plasma glyc-apoB than glycaemia Statin-induced changes in its level may be important in decreasing apoB glycation in diabetes These findings may explain the small effect of improving glycaemia relative to statin treatment in reducing atherosclerosis risk in type 2 diabetes and the increased risk in MS even before the onset of type 2 diabetes
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