Biochemical Studies on the Effect of Some Drugs Affecting Uric Acid Metabolism in Normal & Hyperlipemic Animals

work includes the biochemical effects of phenyl-butazone and allopurinol as uricosuric drugs on blood glucose, uric acid and lipid fractions plasma and liver in both normal and hyperglycemic rat.The animals were divided into two main groups A and B.Group A : Contained the normal rats and divided into 5 subgroups, each consisted of 6 rats,Two subgroups received oral daily doses of phenylbutazonc; body weight) for 30 and 45 days.subgroups received oral daily doses of allopurinol (50 mg/kgm body weight) for 3u and 45 days.One subgroup received only water suspension of gum tragacanth and propylene glycol (vehicles) and considered as control .Group B : contained the hyperlipemic rats . Hyperlipemia wasinduced by feeding the rats orally a diet contains barley.and corn supplemented with 0.5% cholesterol, 0.5% choric acid and 0.005% thiouracil in drinking water for 45 days.Classification of this group was done exactly as allowed under group A. Control group of this category received only water suspension of gum tragacanth and propylene glycol in addition to the cholesterol, cholic acid diet.