Predictive Value of Some Cardiac Bio-Makers In Diabetic Hypertensive Patients without Acute Coronary Syndrome

Atherosclerotic disease of epicardial coronary arteries is the most common cause of myocardial ischaemia. Coronary blood flow can also be limited by arterial thrombi, spasm and rarely coronary emboli.Ischaemic heart diseases include clinical manifestations of stable angina (SA), acute coronary syndrome (unstable angina and non- ST segment elevation myocardial infarction) and acute myocardial infarction (AMI).Acute coronary syndrome (ACS) is clinically characterized by a sudden onset and the possible recurrence of ischaemic episodes over a period of days, weeks or months followed by the return to a stable or quiescent phase of ischaemic heart disease.Long standing diabetes leads usually to structural and functional abnormalities in vasculature which characterize di-abetic related micro- and macro- vascular complications lead-ing to serious events dealing with coronary, carotid, myocardial infarction stroke indeed morbidity and mortality in those patients (type I and type II).Persistent hypertension is one of the risk factors for stroke, myocardial infarction, heart failure and arterial aneu-rysm. Accordingly abnormalities of blood flow due to athero-sclerotic coronary artery disease, microvascular disease and cardiac arrhythmias will arise.Present study aimed mainly to;1) Stratify certain biomarkers specifity and sensitivity re-garding patients having ischaemic heart diseases (IHD), its clinical manifestations as represented by stable angina, acute myocardial infarction (AMI) and acute coronary syndrome (ACS).2) Focus on the prognostic potential of these biomarkers in diabetic hypertensive patients.Work design of the present study depends mainly in group-ing patient subjects, was as the following where individuals were divided into 6 groups according to their clinical and la-boratory assessments;1) Normal healthy individuals; free of any diseases, served normal control.2) Hypertensive diabetic patients;Individuals having long history of hypertension and diabetes mellitus.3) Acute coronary syndrome patients (ACS);Individuals included subtypes of ACS such as unsta-ble angina and NSTEMI patients.