Immunosuppressant Drugs and Its Effect On Some Experimental Diabetic Complications

The onset of microalbuminuria.2) Release of pro-inflammatory cytokines mainly the expression ofTNF-α and TGF-β1 in kidney tissues, additionally serum level ofIL-1α and IL-6.3) Protein glycation follow up.4) Decline in kidney functions, extent of cellular alteration of renaltissues histologically and insubsequent to alloxanadministration.5) Role of certain agents, represented by MMF(immunosuppressant), curcumenoids (natural product as143antioxidant anti-inflammatory), additionally pyridoxamine(glycation inhibitor) either individually or in combination form.Experimental design of this study was as the following where theanimals were divided into 6 groups;1) After acclimatization of animals for one weeks, diabetes wasinduced through a single alloxan intraperitoneal injection (90mg/kg) and animals which achieved serum glucose level above200 mg/dl were included in the experiment.