Treatment Regimens For Management Of Cerebrovascular Complications Of Diabetes Experimentally Induced In Rats

Neurological complications are among the central problems in DM.Most diabetic patients are affected by neurological disorders. Vasculardysfunction plays a major role in many complications associated withdiabetes.Diabetic neuropathy and neurovascular complications represent amajor health problem. Therefore, Considerable attention has been directed toexplore new therapeutic strategies which can reduce hyperglycemia andassociated neurovascular complications.The present work aimed mainly to:I. Clarify the adverse effects of diabetes on neurovascular outcomes aswell as to address the molecular mechanisms underlying them.II. Evaluate the effect of Resv, either as monotherapy or in combinationwith Rosi and/or Rosu, on modulating neurovascular complications indiabetic and diabetic brain IR rats.III. Investigate the histological changes in cerebral tissue of diabetic anddiabetic brain IR rats.IV. Identify the possible correlations between hyperglycemia,cerebrovascular markers and the other studied parameters.