Formulation and Evaluation of Some Pharmaceutical Dosage Forms Containing Azapropazone

The main problems associated wich the frequent administration of this drug could be overcomed by alternative routes of administration . this could be achieved by avoiding the contact between the drug and the stomach through formulating the drug in topical and rectal dosage forms. the very low aqueous solubility of azapropazone is the main peoblem facing the incorporation of the drug in topical and rectal dosage forms. therfore the aqueous solubility of the drug should be enhanced before formulating the drug in topical and rectal vehicles. PartI: In this part , several techniques have been adopted to improve the aqueous solubility and dissolution of the drug Part II: Formulation and evaluation of certain topical and rectal azapropazone dosage forms.