Effect of Certain Agents on Insulin Level &Other Metabolic Products As Related to Hyperglycemia in Experimental Diabetes Mellitus

The present work was designed lo study the metabolic effects of both catechin (green tea extract) and melamine, in alloxan diabetic ratsBiochemical parameters chosen were : Plasma glucose, total Cholesterol (TC), triacylglyccrol (TG) , lactate, pyruvate, (MDA), NEFA, liver glycogen contents and insulin levels.Experimental animals :Animals were divided into two main groups A und It. ;Each group was future subdivided into 4 subgroups :Group (A) ; (4 weeks treatment) :Subgroup I : Normal, nondiahetic nits, received saline orally and expressed as normal control.Subgroup II: Alloxan diabetic rats, received saline only and served asSubgroup III: Alloxan diabetic rats, received metformin (100 mg/kg) body weight orally and daily for 4 weeks.Subgroup IV : Alloxan diabetic rats received catchin (10 nig/kg) body weight orally, and daily for 4 weeks.