Basic Pharmaceutical Studies on the Availability of Tenoxicam from Different Topical Formulations

Tenoxicam is considered as a member of the non-sreoidal anti-inflammatory drugs (NSAIDs) which used in treatment of several rheumatic disorders as arthitis and rheumatoid arthritis. Chronic administration of this drug causrs several side effevts. these adverse effects include gastric ulceration and change in hepatic and renal functions.The problems associated with the frequent administration of this drug could be solved using alternative routes of administration. this could be achived by formulating the drug in topical vehicles. the problem facing the formulation of tenoxicam in topical preparations is its lower aqueous solubility.Thus , the drug aqueous solubility should be improved before incorporating it in topical vehicles .