Interaction of plasma Proteins supstitutes with Protein

the in vitro release study of tenoxicam from different topical vehicles, it could be concluded that; 1- The effect of different concentrations of viscolizers on the in vitro release of tenoxicam from aqueous solutions was investigated. The results indicated that increasing the polymer concentration resulted in increasing the viscosity of the vehicle and so the drug released was suppressed. In addition, tenoxicam exhibited higher release magnitude in presence of different concentrations of PVA 1700 as compared with the same concentrations of the tested polymers when they were used at the same concentration. The anti-inflammatory activity of tenoxicam aqueous solution in presence of different concentrations of PVA 1700 was evaluated. The results indicated that increasing the concentration of PVA 1700 is accompanied with a reduction in the anti-inflammatory activity of the vehicles due to increasing in the vehicle’s viscosity.