Design of sustained release formulations of some bronchodilators

The principle of sustained release formulationsis to retard the release of drug from the products in a controlled manner so that the dissolution bee owe slower than the inherent rate of absorption. These preparations have many advantages over conventiona1 products including; longer duration of action, reduced occurrance of .side effects, Jess fluctuation in serum concentration, decrea¬sed frequency of dosing and improvement in patient compliance .Bronchial asthma is a chronic disease in which the most important as aspect is a widespread obstruction to airflow . Bronchodilators are the mainstay of asthma therapy . Theophylline is, used widely throughout the world , as the bronchodilator IN the treatment of reversible obstructive airways, Salbutamol have also become estab-lished as a world wide bronchod1ator the treatment