Further Studies In The Synthesis Of Coumarins With Possible Photodynamic Activity

The thesis consists of the following parts:(A) Introduction: consists of:1. Historical aspects of natural f urocoumarins .2. •Chemistry of furocoumarins ,3. Physiological activities including the relation¬ship of molecular configuration to the photo-sensitising activity of psoralens.(B) Aim of the present investigations ’The author illustrate in this part the purpose and basis of the research from the pharmacological and chemical stand point.(C) Discussion:It deals with the theoretical application of the reactions and the schemes adopted for the synthesis of the new compoundsD) Experimental: this includes:I. A. Synthesis of three known reagents which are not easily accessible:P-Toluyl chloriceAnisoyl chlorideBroino ac etophenone.B. Synthesis of three known intermediates:7-Hydro2cy-4-methyl coumarin.7-Beri2oyloxy-4-methy 1 coumarin.8-Bensoyl-7-hydroxy-4-methyl ooumarin.C. Synthesis of four new intermediates: 4-L:ethyl-7~(p~toluylo2cy) coumarin.7~Anisoyloxy-4-tnethyl coumarin7~Hydro2cy~4-methyl-8 (p-toluyl) coumarin.8-Ajaisoyl-7-hydroxy-4-methyl coumarin.