Heparin-Antidiabetic Drug Interaction on Certain Aspects of Carbohydrate Metabolism

This work includes the biochemical effects of albutamide, heparin and the combination of the two drugs on some aspects of carbohydrate metabolism normal and alloxan diabetic rata.Normal Rats:TolbutamideTolbutamide in a dose level of (200 mg/kg body wight) produced a significant decrease of blood glucose level and liver glycogen content.The drug induced a significant increase in liver glucose 6-phoaphatase and liver glycogen phosphorylase activities.HeparinHeparin in dose of 100 units/ 100 gm body weight induced a significant increase of blood glucose level , liver glucose 6-phoaphatase and liver glycogen, activitiesThe drug significantly lowered the liver glycogen content.