The Effect of certain centrally ACI drugs on some Biogenic Amines in Experimental Animals

Studies of N E and dopamine in brain and their involvement in behaviour indicates that alterations obseved in depression certainly might be a Functional insufficiency of biogenic aminesEvidence frolllstudie s of N B tUld dopamine in brain and the~r 1nvolvelllellt in behavioUl” indicates that altee~atiolUli ccOb,:lerye<l .. 1A·· .depression oerta.1nly might be a br>;tunoiional inaUti’1ciencyot biogenic amines.’ .~~e dzu8s.w,re chosen as antidepressants namely a A bic1Clic compound a~ Viloxazine,A tric1clic comoound uS Imipramine and A tetraoyolic compound as Maproti11neThese; three drubs were given to male albino rats in three dose levels. The effeot of these drugs on the level at E. Jm and dopaluine of brtl in. heart and adrella.l glands were studied. The findjng~ of the present worklevel ill the three organs. brl1illj heart and adrenal glands. This decrease in CA may be due to a deorease or ~ blooking the amine reuptake mechanism into tissue stores leading to an increase in the amount of freeN B at the site of the recaptor i.e. blocking tile ~roce8s of inactivation of physiologically released o~ admini::itered ~B leadipg to p(,ttHltiution of NK aotion.