The Effect of Certain Monovalelent and Divalent Cations on Experimentally Induced Cardiac Arrhythmias in Experimental Animals

The effect of four monovalent & three 1-divalent cations on the ECG & electrolyle changes in both serum and cardiac tissuc were investigated2- The effect of mono & clivalent cations on the aconitine centrally induced cardiac arrhythmias were studied using the same previously mentioned parametersThe intracerebroventricular injection of ug/kg aconitine produced biphasic effect an intial phase of bradycardia followed by superaventricular, ventricular tachycardia and ventricular fibrillation at the end, Moreover , it produced significant increase in myocardium sodium and significant reduction in potassium.Now in order to put pits pieces it seems possible that aconitine induces its arrhythmogenic effect through an effect on electrolyte distribution i,e it facilitate the influx of sodium and the efflux of potassium. Moreover, the ability of calcium ions to stimulate catecholamine secretion was reported to be improved by either increase intracellular concentration of potassium or by both of these factors( Douglas, 1968, and Banks,1967)Such changes will inturn enhance the cardiac properties resulting in more pronouneed action potential in the prasencr of some degree of heart block i,e . produces cardiac arrhythmias