Synthesis of New Maleimide and Succinimide Derivatives of Pharmaceutical Interest

This work provides few novel chemical aspects in the chemistry of 2, 3-dichloromaleic anhydride including :1- A new reductive, acylation reaction in which the acid solvent becomes the acylating agent rather than the stronger acyl halides. The new reaction is further illucidated through a mechanistic pathway.2- A novel reductive nitrosation reaction which can he applied as a strategy for synthesis of 2-substitutedaminosuccinimides and their hydrolytic products, (aspectic acid derivatives). A mechanism for formation of 2[N-(nitroso)substitutedamino]-N-arylsuccinimides starting from their hydrazono derivatives is advanced.3- A new sodium borohydraise regioselective reduction of the more sterically hindered imidocarbonyl of certain maleimide derivatives, based on the electronic effects is established.In addition, this work , involves the reaction of hydrazine hydrate and o-phenylenediamine with 3-chloro-substituted aminomaleimide which to the best of our knowledge is carried out to the first time.Also new intermediates and final compounds which are developed in this work have been characterized by microanalysis, ir, 1H-NMR, 13C-nmr and mass spectroscopy.Finally, the antimicrobial testing of some compounds has been carried out and results revealed that some of these compounds showed promising broad spectrum activity.