Spectrophotometric Determination of some Pharmaceutical Compounds Containing Phenolic or/and Amino Groups

PREFACEThe prominent position, occupied by either inorganic cations or organic pharmaceutical ingredients, makes their determination a matter of foremost importance.The used pharmaceutical ingredients having different thera¬peutic actions. Among these compounds, the diuretics and antihypertensive drugs (s pi ro no l act.o ne, hydrochlorothiazide, captopril and furosemide), the antimetabolite used in cancer chemotherapy (fluorouracil), the antianemic pharmaceutical ingredient (iron), the antibiotics and antifungus (nystatin and iodochlorhydroxyquin), the anti-inflammatory (hydrocortisone acetate), the antirheumatic and analgesic (sodi um sal icyla te) a nd the vi tami ns (ascorbic acid and thiamine hydrochloride) ha ve been selected for the study presen ted in this work.The increasing interest for the use of U.V. spectrophotometry, first & second derivative spectrophotometry and first & second differential derivative spectrophotometry in pharmaceutical analysis directed us in solving many problems.Thin-layer chromatography (’TLC) is one of practical technique on which separation is based.Charge-transfer complexes (CTC), require no complicated instruments and give accurate results, with advantage of sensitivity.