Instramental Analysis of Some Antinistaminic Drugs

The thesis falls into three parts :The first part comprises the literature review for the different methods used for the analysis of the investigated drugs. The methods discussed include titrimetry spectrophotometry, potentiometry fluorimetry, paleography and chromatography. An introduction of the theoretical bases of charge transfer complexes and the usage of charge. Transfer complexes in analysis of pharmaceutical preparations.The second part deals with kinetic studies to characterize the outer complexes and the inner complexes of these substances formed with iodine and studying the effects of reaction conditions on the process of transformation. The utilization of conduct metric techniques to identify these transformation processes. The number of the reaction steps and the reaction mechanisms were postulated on the bases of kinetic studies.The reaction sites of the CT complexation were elucidated by IR/FIR, 1H- and 13C-NMR. In most cases the aliphatic nitrogen atoms are the interactive centers; in some other cases the aromatic nitrogen or oxygen atoms are additionally involved in complex formation.The third part deals with the optimum condition necessary for the quantitative analysis of three antihistamines (clemastine, pheniramine and azatadine) in pharmaceutical preparations. Accuracy, precision, sensitivity and reproducibility of the developed method for the different compounds were studied statistically. The method was applied for pure form of drugs and in their dosage forms. The