Biochemical Aspects of Drug Interaction Between Oral Hypoglycemic & Hypolipidemic in Experimental Animals

The present work deals with investigation the interaction between an ant diabetic drug (tolbutamide) and a hypolipidemic drug (nicotinic acid). The effects of both drugs were studied alone and in combination on certain biochemical aspects in normal and alloxan diabetic rats.We assessed the, influence of such drugs on the meta¬bolism through determination of .the plasma level of glucose, lipid fraction (total lipid. phospholipids, triglyceride, total cholesterol, non esterifled fatty acid) as well as plasma electrolytes (ZnZ+, Mn2+, Mg2;, Ca2+).In order to carry out such investigations, rats weredivided into two main groups,: -diabetes was induced in one group by l.P injection of alloxan (150 mg/kg) and the other group was used as normal control. Each of these groups whether, normal or diabetic were devided into four subgroups. The first sub-groups received gum accia and served as cqnjtrol. The other three subgroups received a single oral dose of tolbutamide 200 mg/kg), nicotinic acid (43 mg/kg), and tolbutamide with nicotinic acid in combination. The animals were sacrificed 7, 15, 30 days after drug administration.