Cardiovascular changes Induced by Intravenous Injection of the Insecticide trichlorfon

The cardiovasoular changes induced by intravenous injection of trichlorion in adult male rabbits including the arterial blood pressure, heartrate and ECG Voltage changes were studied. Different pharmacological tools were used in a trial to explain the possible mechanism of action of trichlorfon on these previously mentioned parameters. Catecholamines namely, epinephrine, norepinephrine, and dopamine contents were determined in the adrenal module, heart and brain tissue, electrolytes namely, sodium, potassium, calcium and magnesium contents ere determined in the serum, heart and brain tissue to clarify their role in the mechamis of action of trichlorfon on the cardiovascular system. The main finding of the present investigation can be summarized as follows:1- Intravenous injection of trichlorfon in a dose of 150 mg/kg in adult male rabbits induced biphastic effect on tha arterial blood pressure of rabbits. The4re was an initial phase of hypotension. The initial phase of hypotension stared within a period ranging between 10-15 minutes and lasted for 80-100 minutes after trichlorfon injection. The second phase or hypertension started witin a pertiod ranging between 110-120 miuntes and lasted for more than 9 hours. Moreover, it induced a pronounced bradyearidia accompanied by EGG voltage changes.