Synthesis of certain fused Heterocyclic Compounds of Pharmacological Interest

Ageneral Survey of different methods of Prepartion of s-triazoloe(3,4-b)-1,3,4-thiadiazine and s-triazolo-(3,4,-b)1,3,4-thiadiazole derivatives is representedA general survey of the different methods of preparation of s-triazolo-[3,4-b]-1,3.4-thiaiazine and s-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives is represented .A critical discussion and detailed survey for the experimental results attained with an adequate interpretation is advanced . Moreover some of the prepared new compounds were subjected to pharmacological and antimicrobial testing and the results obtained are summarized .The present investigation involves the synthesis of some unavailable starting materials and intermediates e.g. Ethyl nicotinate & Nicotinic acid hydrazideThe present study comprises also the synthesis of some new final compounds e.g. 6-p-Bromophenyl-3-phenoxymethyl-7H-s-triazolo-[3,4-b]-1,3,4-thiadiazine