| Abstract: |
Microencapsulation, a process whereby drugs, in the form of small solid particles or liquid DROPlets, are surrounded by an intact coat, is used in pharmaceutical industry for several purposes. Some of these purposes are, to separate reactive materials, to isolate a product from a medium with which it can react, to mask the taste for a short time, or to obtain a delayed release effect in gastric or intestinal fluids, and many others. In general, the choice of the wall material, an operating conditions of the microcapsules should be carefully considered in’ order to reach the expec¬ted objective, and- solve the problem involved.In this research the drug used was N-acetylcysteine, (NAG), the antidote of choice for paracetamol (acetarninophen) toxicity resulting from acetaminophen overdosage, .Although paracetamol is the safest anelgesic when used in normal doses, yet as little as 10 grams in a single dose can injure the liver and 12 to 15 grams were found to be fatal. The increased use of paracetamol compared to other analgesics . has resulted in marked abuse for suicide by young adults.N-acetylcysteine (NAG) is preferably given orally.To be effective as an antidote for paracetamol, it must be given in, massive oral doses ranging from 20 -to 4-0 percent the drug to be detoxified.
|
|
|