Pharmacological studies on the possible Interactions between some antidiabetics & certain psychotrdpic drugs

The possible interactions between some antidiabetics represented by insulin and tolbutamide and certion psychotropic drugs namely chlorpromazine , Fluphenazine & triflupromazine on blood Glucose , serum immunoreactive insulin , serum thyroxine and triiodothyronine levels in normal and albxan - diabetic rabbits .andtriflupromazin~. 0,0 blood glucose, serum irnmunooflteactiveinsulin, ~eruhthyrJxioe and triiodo,thyronine ;~,,” ~levels in normal a~d alloxan-diabetic rabbits was studie~.adrnini strat 1-on along Wi. th e il:her insul in or tolbuta~id~ resulted 1-D significanc hyperglycemia.adrninist,.ration of in,sulin o£:” tolbutamide resulted in.’:”:-’;’signiflG,ant eleva’tion i,f serum irrutl’.moreactite insulin’.When chlorp~p~azjne ,was administered together~ Jwith insulin, ther:ewa:; still significant elevation of ”1serum immunoreactive iLsulin levelal thoughj’chlorpromazine