Analytical Study of some Adduct Forming Pharmaceutical Compounds

I.A. introduction :the term adduct denotes a very wide range of interactions – mainly molecular – varying in principles of interactions. Forces and mechanisms of formation and stability of products and interactions. This concept allows for the diversified approaches and treatment of substances in this thesis.Many substances of very diverse structures are succep tible for association with compounds of various nature to give adducts or inclusion compounds (1).Classically, the term inclusion compounds denotes substances which do not constitute combinations in the known sense, the stability of the structure is attri-buted to different factors, among which , is the van derwaals forces (2,3) .Inclusion compounds consist of an included substance surrounded from all parts by host molecules forming what is termed guest and host model. Geometrical factors such as size and shape of the molecules are of basic importance in forming inclusion compounds. But chemical nature and affinity play only minor roles(4).