Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives

Faculty Pharmacy Year: 2010
Type of Publication: Article Pages: 1025-1035
Authors:
El-Sabbagh, Osama I, Ibrahim, Samy M, Baraka, Mohamed M, Rashad, Adel A, Mostafa, Ahmed, Pannecouque, Christophe, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan
DOI: 10.1007/s00044-009-9248-y
Journal: MEDICINAL CHEMISTRY RESEARCH BIRKHAUSER BOSTON INC Volume: 19
Research Area: Pharmacology \& Pharmacy ISSN ISI:000284432000001
Keywords : Synthesis, Antiviral activity, N-phenylpyrazoles, Dihydroisoxazole, Herpes simplex virus type 1, Hepatitis A virus    
Abstract:
A new series of N-phenylpyrazoles and dihydroisoxazles was synthesized starting from alpha,beta-unsaturated ketones in basic media using phenyl hydrazine and hydroxylamine HCl, respectively. Antiviral evaluation of the target compounds revealed that the dihydroisoxazole derivatives have promising antiviral activity against hepatitis A virus and herpes simplex virus type 1.
    
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