Studies of Certain Adsprption Phenomena In Some Pharmaceutical Formulae

The preceding study was an attempt to evaluate the potential of the use of niosomes (NIS Vs) as delivery systems to enhance the effect and prolong the action of the anti-inflammatory drugs as diclofenac sodium and piroxicam, In-vitro evaluation of these systems is an important pre-requisite before in-vivo administration. An optimum formulation encapsulating a high percentage of the drug which could be released at a controllable rate in-vivo over a prolonged period of time, (Tween 60/Span 60/Chol in a molar ratio of 23/25/50 for diclofenac sodium and Span 40/Chol/SA in a molar ratio of 45/45/10 for piroxicain), could then be considered for use in n clinical evaluation.