Interactions of Certain Antihistaminic Drugs With Certain Polymeric Materials

many of various types have gained wide spread use allover the world. The diminish and prevent several of the harmful pharmacological effects of histamine. Furthermore, many antihistamines have other pharmacological properties, largely independent of antihistamine activity, including anticholinergic, antiadrenaline and antiserotonin effects, Antihistamines are widely included in many pharmaceutical formulations .Recently a number of pharmaceutical scientists have focussed their attention upon interactions between drugs and polymers. Such interactions have a bearing in determin¬ing a pharmaceutical formulation. Interactions between drugs and polymers are utilised , in pharmaceutical tech¬nology, for the preparation of sustained as controlled release dosage forms. Also, an understanding of the , forces involved in drug polymer interaction is likely to be of considerable value in studies of plasma binding and drug receptor theory.