Synthesis of certain triazole and oxadiazole derivatives for Pharmaceutical study

Ageneral Survey of the different Pharmacological activities and the Chemistry,including Synthesis and Properties of 1,2,3-Oxadiazole and 1,2,4-tricizole ring system is presented.The present investigation involves the synthesis oi’ tae following unuvui Lcib I e and not easily accessible .s tar t i ii(’; umtei’ials arid in tei’ineiiia tes :l) Ethyl nLcotiiiate.2) Nicotiiiic acid hydravcido.3) Benza Idehyde nicotinic acid liydi’ay;one .4) o- chlorobenzaldchyde cotLnLc acid hydrazone .5) p-Ch l.orobenxa Lflohyde acid hyfrazone6) m-Nitrobenzaldehyde Ldehyde nicotinic acid hyda.one.7) p-Ni troben/.aldehyde nicotinic acid hydriiy.one. ti p-lly 8) p-Nioxybeiiza Ldehyde nicotinic acid hydrazone.9) Cye Lohoxarione nicotinLe acid hydrax.one. to10 ) Methyl ethyl ketone iileotinic acid one .11) Aeetophenone nicotinic ac Ld tiydi’ax. oiu;.12) Acetone riicoLinic acid13) N-Phoiiy Icli 1 or-oace tain i dir140 N-o-To L Lch I o roace tain xN-in-To 15 ) n-M-tolyloi’oace tamlde .