Pharmceutical Aspects of Certain Cephradine Formulations

Cephradine is one member of the senisynthetic cephalosporins belonging to the beta-lactan group of antibiotics which includes also the penicillins and cephamycins. Cephalosporins are usually effective against infections from Gran-positive bacteria, such as Staphlococci , group- A Sterptococcus , anaerobic Streptococci , and Streptococcus pneumoniae . Cephradine is the only cephalosporin that can be administered both orally and parenterally . It is well absorbed from both routes, as evidenced by recoveries of approximately 100 percent of the administered dose in urine. It is usually given in an amount of 1 to 4 g daily in four divided doses. Under dry and cool storage conditions, with the exclusion of oxygen, it shows reasonable bulk-stabilityIn the present work, it was intended to carry out a pharmaceutical investigation of Cephradine in certain formulation. Such as investigation was dealt with the following headings