A Study of the Effect of Calcium Channel Blockers on Some Metabolic Aspects of Carbohydrates & Lipids in Experimental Rats

This study has been carried out to demonstrate the effect of calcium channel blockers such as nifedipine (dihyDROPyndines) and diltiazem ( benzohiazepines ) on certain biochemical parameters in normal and alloxan induced diabetic rats. All animals were treated with drugs ,under study for 15, 30, and 15 days. The following biochemical parameters were determined:I- Plasma glucose levels. . .2- Glycated hemoglobin3-Plasma lipids (total, IIDL-, LDL-cholesterol, and triacylglycerol).4- Plasma and liver lipid peroxide (MDA5- liver glycogen contents (15 days)6-Thc activity of glycogen phosphorylase and ghicose-6-phosphatase enzymes in the liver tissue (45 days).7- Plasma insulin, C-peptidi, and glucagons hormones.Generally, rats received alloxan had significantly higher levels of plasma glucose, total cholesterol, LDL – cholesterol triacylglycerol, MDA, glucagons hormone liver glycogen phosphoiylase, and glucose-6-phosphatase activities. While liver glycogen contents, plasma HDL-cholesterol, insulin, and C-peptide hormone demonstrated significant decrease in comparison to normal groups.