A Study of Some Agents Affecting Hemostasis in Experimental Diabetes Mellitus

present study represents a trial to correlate the blood coagulation factors and changes in lipid and lipoproteins parameters in diabetics.This work has been carried out to study the effect of acetyl salicylic acid alone, n-3 polyunsaturated fatty acid, alpha-tocopherol and xanthinol nicotinate individually and their combinations with acetylsalicylic acid on certain biochemical parameters in STZ diabetic rats plasma glucose, Lp(a), fibrinogen, AT III and plasminogen, TC, TG.LDL-C and HDL-C. RBCs MDA, Blood GHb% and platelet cholesterol phospholipids ratio (C/P ratio) were used as parameter for Evaluation of drugs under study.Experimental animals :Diabetic animals were classified into three main parts, each oneare classified to nine subgroups and 60 days as follow:1. Normal group received olive oil.2. Diabetic group received olive oil.3. Received ASA (162.5 mg/day).4. Received n-3 fatty acid (4 g/day)