1,3-Cyclic Diketones as starting synthons for synthesis of heterocyclic Compounds of Pharmaceutical Interest

Considerable interests have been focused on the chemistry of enaminones having aliphatic residues at 3- position These enaminones are of great value in drug synthesis. Our main objective in this dissertation is the development of new synthetic methods for varieties of geterocyclic compounds which are of potential biological significane .Onthe other hand , this work is acontinuation of arecent study on aromatic enaminones which might give rice to useful insights in both pharmacological and organic chemistry .The new chemical aspects entertained in this dissertation are summarized as follows :Synthetic strategy of awide scope for pyrazole and indazole derivatives. The developed synthetic method is based on intramolecular Michael type cyclization followed by elimination .The work is published in Bulottino Chemico Farmacio Milano (1996).2-The reaction of aliphatic enaminones with aromatic aldehdes in actic acid showed anomales behavior . Formation of acidines only in the case of N- benzylenaminones. On the other hand , n-propy or n- cyclohexyl enaminones gave the corresponding xanthenes . An attempt to prepare acridines from xanthenes by aminolysis with aliphatic amines gave only N- benzylacridines.3-This work establishes the optimum conditions and expands the synthetic procedures for synthesis of quinazolinones.4-this dissertation also involves the design and application of anew synthetic process for tetra- substited ethylenes in good yield starting from accessible cyclic -1,3- diketones and in situ arylidene derivatives of B-diketones or B- ketoestres .Liewise ,asmiar reaction of 1,3 – diketne with aryidene ethyl cyanoacetates and malononitrile afforoed the corresponding iminocoumarineThe above chemical behavior of arylidene derivatives might be explaned on the basis of the differences in stability of Michael adducts .