Spectrophotometric Determination of some 8-Hydroxyquindines and Dibenzazepines using certain Diazonium Salts

In this thesis two simple , rapid, reproducible and accurate spectrophotometric mothods were developed involving the use of fast red AL salt and diazotized 4- amino-6-chloro-1,3-benzene disulphonamide DACBS)as chromogenic reagents for the analysis of 8-hydroxyquinoline derivatives, namely, oxyquinoline, clomipramine, desipramine and imipramine hydrochlorides and trimipramine maleate.The proposed methods are based on the interaction of either fast red al salt or DACBS reagent with the investigated 8-hydroxyquinolines to form intense red coloured products measured at λmax(s) in the range of 500-530 nmDibenzazepines give no coloured products with fast red al salt, while they form intense red coloured products measured at λmax(s)in the range of 519-555nm with DACBS reagent.The interaction between 8-hydroxyquinlion derivatives and both reagents was performed in slightly alkaline media while DACBS reagent was interacted with dibenzazepine derivatives in strongly acidic solutions. Pharmacognostical study of Merendra persica Bioss corms.