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DNA damage of blood lymphocytes and neutrophils in cattle with lymphosarcoma
Faculty
Veterinary Medicine
Year:
2011
Type of Publication:
Article
Pages:
504-509
Authors:
MOHAMED, T, Oikawa, S, Endoh, D
Journal:
VETERINARNI MEDICINA CZECH ACAD AGRIC SCI
Volume:
56
Research Area:
Veterinary Sciences
ISSN
ISI:000297751900003
Keywords :
apoptosis, cattle, lymphocytes, lymphosarcoma, neutrophils
Abstract:
The objective of the present study was to analyze the apoptotic process in peripheral blood mononuclear cells (PBMC) and polymorphonuclear neutrophil leukocytes (PMN) in cows clinically affected with lymphosarcoma. Thirteen cows were studied. Of them, eight, that were referred because of inappetance, loss of body condition, diarrhoea, constipation, protrusion of third eyelid, and exophthalmia, were seropositive for bovine leukemia virus (BLV) based on a serum enzyme-linked immunosorbent assay. Other animals were apparently healthy and were used as controls. DNA damage of PBMC and PMN was assessed using the Comet assay. The results obtained showed a statistically significant difference in DNA damage between the PBMC and PMN isolated from cows infected with BLV compared to PBMC and PMN isolated from healthy cows. This is the first article to document decreased apoptosis of blood PBMC and PMN in cattle in response to BLV infection using the Comet assay.
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