Formulation & Evolution Of Antigloucoma Drug For Topical Applicaion

The rational of the present work is to formulate the drug in a new type of dosage form such as micro emulsion, this was our way and method to increase its contact to the cornea, giving longer time of drug contact to, the eye and slow possible release from the preparation.Systematic studies addressing the ”different design. and formulation ’’parameters in a micro emulsion in-vivo performance are still awaited. The present thesis is a contribution aimed at the proper understanding ofdesign-performance or formulation-performance relation ship in a .micro emulsion.This contribution has been coupled with the growing interest in recent years to develop new, drug delivery systems for ophthalmic application because of the standing need for an ocular drug delivery system which has the convenience of a DROP but will localize and maintain drug activity at its site of action. The foregoing considerations were sufficient to direct the research towards putting micro emulsions to test, in ophthalmic application, utilizing antiglaucoma drug, nadolol. For this purpose, nadolol is subjected to a formulation and evaluation studies.