A Contribution to the Mechanism of action of Lithium in Experimental Animals

The intracercbroventrioul~r injection~f 20 1~200 gm hemicholiniurn produced an increase in locomotor and rearing activities. Such effects were decreased in case of treatment with acute rold subacute injections of lith-serum sodium end signifi.co.nt rp.duction in brf\in sodium.nium produced Btgnificnnt reduction in both serum find brain sodium while 8ubac u.te 1i thium produced nonsignifficant increase; in SerU111 and si.gnificant decrQ$J.se in brain sodium. On tho other hfmd J both acute and 6ubfl,cute li thhium produced significant elevE’.tion in both serum e.nd brrain potassium.challenge,d with hHmicholinium produced significe.nt elevvation in serlilll celciwa level. On contrary, it produceduviour was poteDtinted by the ~cut.e pnd 8ubucut0 trent-ment wi.th lithiu~ chlDl’ida. 1\Iloruo’Jer, f’.utonom1c chenges